Search results for "Delayed puberty"

showing 3 items of 3 documents

Hypogonadism in β-thalassemic adolescents: A characteristic pituitary-gonadal impairment. The ineffectiveness of long-term iron chelation therapy

1990

The pituitary-gonadal function was studied in 18 beta-thalassemic female adolescents, 8 with delayed puberty and 10 with primary amenorrhea,treated with repeated transfusions and long-term iron chelation therapy by subcutaneous infusion. A 100 micrograms gonadotropin-releasing hormone (GnRH) test, a double-bolus GnRH test after estradiol administration in non-responders, a 400 micrograms thyrotropin-releasing hormone (TRH) test and a 'high dose' human menopausal gonadotropin (hMG) test were performed. LH and FSH peak levels were significantly lower in thalassemic patients than in controls, both in the 100 micrograms GnRH test (LH was 4.3 +/- 0.7 mIU/ml vs 40.8 +/- 6.0 mIU/ml and FSH 3.3 +/-…

Delayed pubertyendocrine systemmedicine.medical_specialtyMenotropinsAdolescentendocrine system diseasesmedicine.drug_classIronEndocrinology Diabetes and MetabolismDeferoxamineGonadotropin-Releasing HormoneGnrh testEndocrinologyTRH stimulation testInternal medicinemedicineHumansChildThyrotropin-Releasing HormoneDose-Response Relationship DrugEstradiolbiologybusiness.industryHypogonadismOvaryObstetrics and GynecologyIron chelation therapyLuteinizing HormoneChelation TherapyProlactinProlactinEndocrinologyPituitary GlandHMG-CoA reductasebiology.proteinThalassemiaFemaleFollicle Stimulating Hormonemedicine.symptomGonadotropinbusinesshormones hormone substitutes and hormone antagonistsHormoneGynecological Endocrinology
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HeterozygousFGF8mutations in patients presenting cryptorchidism and multiple VATER/VACTERL features without limb anomalies

2014

Background The acronym VATER/VACTERL association describes the combination of at least three of the following cardinal features: vertebral defects, anorectal malformations, cardiac defects, tracheoesophageal fistula with or without esophageal atresia, renal malformations, and limb defects. Although fibroblast growth factor-8 (FGF8) mutations have mainly found in patients with Kallmann syndrome, mice with a hypomorphic Fgf8 allele or complete gene invalidation display, aside from gonadotropin-releasing hormone deficiency, parts or even the entire spectrum of human VATER/VACTERL association. Methods We performed FGF8 gene analysis in 49 patients with VATER/VACTERL association and 27 patients …

Delayed pubertyEmbryologymedicine.medical_specialtyKallmann syndromeTracheoesophageal fistulaGeneral MedicineBiologyUnilateral cryptorchidismmedicine.diseaseVACTERL associationGastroenterologyHypergonadotropic hypogonadismEndocrinologyInternal medicineAtresiaPediatrics Perinatology and Child HealthGene duplicationmedicinemedicine.symptomDevelopmental BiologyBirth Defects Research Part A: Clinical and Molecular Teratology
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Parenterale Ernährung in der Behandlung des Minderwuchses bei Adoleszenten mit Morbus Crohn

1992

Growth retardation and delayed puberty occur in 20-35% of children and adolescents with Crohn's disease. Alternate day corticosteroid treatment, use of azathioprine, enteral or parenteral hyperalimentation and surgery have been advocated to reverse growth failure. Because of nonacceptance of elemental diet 7 patients with Crohn's disease and growth retardation received parenteral nutrition for 2-3 months (maximal for more than 30 months in one patient). All of them exhibited a mean weight gain of 10 kg and a mean increase of their height velocity from 2.4 to 7.1 cm/year. Main problems were bacterial infections and dislocations of the central lines. Surgery was performed in 3 adolescents imm…

Delayed pubertyPediatricsmedicine.medical_specialtyElemental dietbusiness.industryAzathioprineShort statureEnteral administrationGastroenterologyRegimenParenteral nutritionInternal medicinePediatrics Perinatology and Child Healthmedicinemedicine.symptombusinessWeight gainmedicine.drugKlinische Pädiatrie
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